Our Promises to You:
- MADE WITH INTEGRITY
- ETHNOBOTANY & CHEMISTRY COMBINED
- WE'LL MAKE IT RIGHT
Your ancestors knew maintaining clarity of though and peace of mind would lead to understanding the secretes of the universe and their place in it. Think like the ancients did!
The Celestial Story
He could feel the rock cooling beneath him as the last bit of the day’s sun-fired warmth disappeared into the night. Above him, countless stars shined bright from a moonless sky. But even brighter than the stars was the biggest of the five wandering lights, who’s paths moved differently than the innumerable yet predictable stars. But tonight was different. Tonight those wanderers were where he had predicted they’d be. This was a feat deemed impossible by the tribe’s leaders and spiritual guides…they believed the movements of those nomadic lights were inexplainable and to attempt otherwise would end in ruin. The universe was wild and unpredictable. To think otherwise was a foolish challenge against those unseen and unfriendly powers.
But after careful study felt he had deciphered their tracks. Explaining his predictions to the tribe resulted not in excitement but abuse. It was feared his hubris would drawn down Bad Things. He was ostracized, belittled, and battered. Only one person did not turn on him, only one person gave him help…the healer. She had long been supplying the sky watcher with a special mixture that helped him keep the complicated thoughts, observations, and calculation straight. When the ridicule started causing self-doubt she added more to the blend which seemed to add iron to his spine. He shrugged off what once scared him and focused on his task. He would understand the universe.
In our modern age, just as with our ancestors, a calm, focused mind leads to great things. But nowadays there’s so many things to worry about…money, food, war, the future…sometimes it seems like a hungry saber-toothed tiger would be easier to handle! Humans are intelligent and it seems like the more intelligent one is the more things the brain starts to worry about. This has ALWAYS been the case. The threats have changed but our brain’s overthinking to identify threats is part of us down to the genetic levels. Thankfully, problem-solving and pattern recognition also is programmed into us which allowed the ancients to find ways to brain sharp and focused without the fear. Certain plants and mushrooms were identified across many early people to the point where co-evolution occurred. Those that responded best to the plants became the fittest and so past those genes on over and over. This means most of us are genetically designed to respond to these ancient treatments.
But two hundred years ago a change occurred. Herbalists became scientists and scientists began unlocking what they thought were the secrets of the universe. The plants were torn down into individual molecules and then even these molecules were rebuilt into new things never imagined by nature. The economics of synthetic mass production replaced the tribal healer. The scientists had some great successes but at what cost overall? Today we are finally coming full circle with the understanding from diversity comes strength. The multitude of compounds in the plants we evolved using have power beyond that of a single molecule.
The Brain Pill Components
LION’S MANE The mushroom Hericium erinaceus aka lion’s mane is found growing wild across many parts of the world. Rather than looking like a traditional toadstool, these fungi resemble a cluster of small, white tubes giving the appearance of a round, albino hedgehog growing off the side of a tree. The earliest records of the mental support offered by these odd fungi can be traced to ancient China. Although the whole mushroom is edible and unbelievably delicious, when used to maintain mental acuity they were brewed into a simple tea.
β-glucan polysaccharides: This water-soluble class of compounds are the key source of lion’s mane’s power. Studies have shown these polysaccharides are the anti-cancer, immuno-modulating, hypolipidemic, antioxidant, anti-microbial, anti-hypertensive, anti-diabetic, wound healing, and neuro-protective agents of Hericium erianceus.*(1) The potent brain support comes from maintaining and even increasing neural connectivity while also helping clear the brain of damaging compounds, leading to improved spatial and visual memory.*(2) These benefits were found in elderly patients as well as people with Alzheimer’s and Parkinson’s.*(2) Motor control improved in extremities that had suffered nerve damage.*(2) For consistency The Immune Pill uses a scientifically controlled hot water extraction of lion’s mane mushrooms followed by careful removal of the water. This ensures the concentration of β-glucan polysaccharides in the capsule meets our special requirements to best serve your needs.
GINKGO There’s something special about this ancient tree. Fossil records put it back to 270 million years ago, well before the evolution of humans as well as many other things currently living on the planet. An individual tree can live over 1500 years, as proven by examples grown in Chinese, Korean, and Japanese gardens. Use in traditional Asian medicine goes back even farther. It’s this use that has helped preserve ginkgo trees when humans have sent so many other species into the abyss. While ginkgo has been used by Asian healers for circulatory disorders, asthma, tinnitus, and vertigo, its main use is for mental/cognitive support such as autism, ADHD, addiction, anxiety, schizophrenia, and dementia.*(3)
Research suggests the neuro-benefits of ginkgo are due to several mechanisms triggered by multiple compounds. Increased blood flow to the brain is one.*(4) Presence of the monoamine oxidase inhibitor kaempferol may also play a role.*(5) Compounds from ginkgo have also been shown to modulate the over-expression of cerebral proteins associated with Alzheimer’s.*(6) Whatever the actual chemistry may be, the end result has been known and used for a long, long time.
SAGE The history of Salvia officinalis reaches back to pre-Roman times along the Mediterranean Sea. By the times the Roman culture appeared it already was known as the “holy herb” used as a local anesthetic of the skin, a diuretic, and to stop bleeding. The ancient philosopher/doctors Dioscorides, Pliny, and Galen all wrote of its powers. Because of the rich flavor of sage’s compounds such as cineole, borneol, thujone, tannic acid, oleic acid, ursonic acid, ursolic acid, carnosol, carnosic acid, fumaric acid, chlorogenic acid, caffeic acid, niacin, nicotinamide, flavones, and flavonoid glycosides its usage moved from healer to the cook…and to those who required a sharp mind.
Research has shown sage assists with attention, memory, judgment and evaluation, reasoning, problem solving and decision making through a large diversity of mechanisms.*(7) Compounds exert cholinergic, neurotrophic, anti-inflammatory, antidepressant, anxiolytic, antioxidant effects on the brain as well as reducing the damage done by amyloid-β peptide clusters of Alzheimer’s.*(4)
The mixture of phenolic acid and flavoids , rosmarinic acid, salvianolic acid, carnosic acid, and quercetin work together to return memory functions in those showing signs of Alzheimer’s by slowing the growth of amyloid-β peptide clusters which results in a reduction of the damaging compounds these clusters produce.*(7)
Acetylcholine is a primary neurotransmitter of the cholinergic signaling system in the brain. This system plays a large role in mood, memory, and general motivation. The enzyme AChE breaks down acetylcholine. When AChE becomes overexpressed the availability of acetylcholine drops below what is necessary for normal cognitive functions. Rosmarinic acid, carnosic acid, and quercetin inhibit the action of AChE, maintaining normal levels of acetylcholine.*(7)
Neurotrophins are the general name for the compounds that regulate neuron development, functioning, adaptability, and survival. In other words, they build and maintain the amazing computer circuitry of your brain. Brain-derived neurotrophic factor (BDNF) is a compound in the brain found to assist the proper growth and functioning of neurons. Reduced levels of BDNF result in impaired metal ability. The rosmarinic acid in sage increases BDNF levels back to operational levels.*(7)
Brain inflammations have been found to correspond with assorted neurological impairments including ADHD, reduced motor control, depression, and acute phase psychosis. The 1,8-cineole, camphor, carnosol, and carnosic acids found in sage reduces these inflammations, usually through reduction of cytokine expression.*(7)
Rosmarinic and caffeic acids, also both display antidepressant and antianxiety activity. All that is known about the actual mechanisms of these plant compounds is that they don’t function like the monoamine oxidase inhibitors created in the lab.*(7)
Together, the combination of lion’s man mushroom, ginger, and sage in The Immune Pill work across a diversity of mechanisms to maintain your cognitive abilities. The doses of the individual components were set to give your body enough of the plants & mushroom necessary for the proper effect without over or under-representation. Ancient wisdom and modern science come together, unearthing the ancestral secrets used to maintain the tribe’s health. You are part of this tribe!
(1) Hericium erinaceus: an edible mushroom with medicinal values https://www.degruyter.com/view/journals/jcim/10/1/article-p253.xml
(2) Neurological Activity of Lion’s Mane ( Hericium erinaceus ) https://www.researchgate.net/publication/321969743_Neurological_Activity_of_Lion's_Mane_Hericium_erinaceus
(3) A Systematic Review and Meta-Analysis of Ginkgo biloba in Neuropsychiatric Disorders: From Ancient Tradition to Modern-Day Medicine https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679686/
(4) Neuroprotective effects of Ginkgo biloba extract https://pubmed.ncbi.nlm.nih.gov/14523543/
(5) Identification of kaempferol as a monoamine oxidase inhibitor and potential Neuroprotectant in extracts of Ginkgo biloba leaves https://pubmed.ncbi.nlm.nih.gov/10813558/
(6) Gingko biloba Extract (EGb) Inhibits Oxidative Stress in Neuro 2A Cells Overexpressing APPsw https://pubmed.ncbi.nlm.nih.gov/31380435/
(7) Salvia (Sage): A Review of its Potential Cognitive-Enhancing and Protective Effects https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318325/
The Serenity Pill Components
ASHWAGHANDA effects aren’t instantaneous, but can take several weeks to develop. Once they do, the world becomes a better place. Along with mood, improved memory is also reported.*(1,2,3,4,5, 6) Not remembering a person name or important details can increase anxiety.
Its powers don’t stop there. Withania somnifera extracted from ashwaghanda roots has also been shown increase in muscle mass and stamina.* (7, 8) People feel stronger and capable of taking on the world, resulting in increased self-assurance. Not just muscles but also the immune system reaps benefit from ashwaghanda. Its root extract has been shown to increase Natural Killer Cells, a key component of the immune defensive system.* (9, 10) Staying healthy while others fall helps build a sense of self-confidence.
NUTMEG This is the powdered nuts of the Indonesian tree Myristica fragrans. Originally only available from several secret islands, the demand for the sweet, powerful spice resulted in much bloodshed as different nationalities fought for control of the lucrative nutmeg trade. It contains a large number of beneficial, bioactive compounds but also tastes great, making it both pleasant and medicinal.
The anti-depressant powers of nutmeg are due to its compounds interacting with the adrenergic, dopaminergic, and serotonergic systems, increasing the amount of “feel good” neurotransmitters in the brain* (11, 12) Perhaps the inclusion of nutmeg in many holiday dishes causes some of the good will associated with those times of year!
Compounds in nutmeg have been found to help maintain good gut flora while reducing bad ones.* (13, 14) Correlations have been found between proper, healthy gut bacteria and mood.* (13) Happy stomach flora, happy mind!
Another source of happiness comes from physical contact. Along those lines, research supports nutmeg having a positive effect on libido by making the brain more sensitive to pleasurable sensations.* (14, 15) The mechanism of this effect hasn’t been determined but its use definitely has been.
Chronic inflammation can wear down a person down psychologically. Nutmeg powder includes monoterpenes such as sabinene, terpineol, and pinene and cyanidin and phenolic antioxidants, all of which are potent anti-inflammatory agents, helping to reduce inflammation irritation.* (16, 17, 18)
PASSIFLORA INCARNATA Purple passion (Passiflora incarnata) flowers vines been used by southeastern Native Americans, where the local Native Americans at the fruit and used the flowers & leaves for strong medicine. The main organs affected by Passiflora tea are the brain and nervous system. Here, due to assorted neurotransmitters such as gamma-aminobutyric acid (GABA) found in the vine, a calming effect occurs. (19) Medicine Man Plant Co. freeze-dried the tea to remove the water without damaging the comfort-inducing compounds. In the modern world time is treasure and we want you to have a rich life. There is something to be said about developing peaceful tea rituals but if you’re already worried about getting everything done then a capsule containing the same compounds is the way to go.
GREEN TEA EXTRACT Sometimes calm leads to sleepiness. Since much of the day requires a clear head, a bit of freeze-dried green tea (Camellia sinensis) was also included in the formulation. The dash of caffeine found in it will help with attention and counteract potential drowsiness. Green tea is also known to contain L-theanine, which has been found to offer anti-anxiety properties.* (20, 21) Camellia sinensis comes originally from south Asia to central China but has spread around the world due to how good it makes people feel.
Green tea extract is high in all-natural epigallocatechin gallate (EGCG), a metabolism-boosting antioxidant. This compound creates a feeling of energy as it promotes the increased burning of fats, even while at rest.* (22)
(1) Direct evidence for GABAergic activity of Withania somnifera on mammalian ionotropic GABAA and GABAρ receptors https://pubmed.ncbi.nlm.nih.gov/26068424/
(2) A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults https://pubmed.ncbi.nlm.nih.gov/23439798/
(3) Naturopathic care for anxiety: a randomized controlled trial ISRCTN78958974 https://pubmed.ncbi.nlm.nih.gov/19718255/
(4) A double-blind, placebo-controlled evaluation of the anxiolytic efficacy of an ethanolic extract of withania somnifera https://pubmed.ncbi.nlm.nih.gov/21407960/
(5) Oxidative stress induced NMDA receptor alteration leads to spatial memory deficits in temporal lobe epilepsy: ameliorative effects of Withania somnifera and Withanolide A https://pubmed.ncbi.nlm.nih.gov/22700086/
(6) Ashwagandha (Withania somnifera) reverses β-amyloid1-42 induced toxicity in human neuronal cells: implications in HIV-associated neurocognitive disorders (HAND) https://pubmed.ncbi.nlm.nih.gov/24147038/
(7) Examining the effect of Withania somnifera supplementation on muscle strength and recovery: a randomized controlled trial https://pubmed.ncbi.nlm.nih.gov/26609282/
(8) Effects of Withania somnifera (Ashwagandha) and Terminalia arjuna (Arjuna) on physical performance and cardiorespiratory endurance in healthy young adults https://pubmed.ncbi.nlm.nih.gov/21170205/
(9) In vivo enhancement of natural killer cell activity through tea fortified with Ayurvedic herbs https://pubmed.ncbi.nlm.nih.gov/19504465/
(10) In vivo effects of Ashwagandha (Withania somnifera) extract on the activation of lymphocytes https://pubmed.ncbi.nlm.nih.gov/19388865/
(11) Antidepressant-like activity of n-hexane extract of nutmeg (Myristica fragrans) seeds in mice https://pubmed.ncbi.nlm.nih.gov/16579733/
(12) Evaluation of the anti–depressant activity of Myristica fragrans (Nutmeg) in male rats https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4075663/
(13) Gut microbiota in autism and mood disorders https://pubmed.ncbi.nlm.nih.gov/26755882/
(14) An experimental study of sexual function improving effect of Myristica fragrans Houtt. (nutmeg) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1187868/
(15) A Review on Plants Used for Improvement of Sexual Performance and Virility https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151601/
(16) Chemical diversity and pharmacological significance of the secondary metabolites of nutmeg (Myristica fragrans Houtt.) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5222521/
(17) Anti-inflammatory effects of dietary phenolic compounds in an in vitro model of inflamed human intestinal epithelium https://pubmed.ncbi.nlm.nih.gov/20816778/
(18) Antioxidant and Antiinflammatory Compounds in Nutmeg (Myristicafragrans) Pericarp as Determined by in vitro Assays https://pubmed.ncbi.nlm.nih.gov/26434127/
(19) Preoperative oral Passiflora incarnata reduces anxiety in ambulatory surgery patients: a double-blind, placebo-controlled study https://pubmed.ncbi.nlm.nih.gov/18499602/
(20) Effects of l-theanine on attention and reaction time response https://www.sciencedirect.com/science/article/pii/S1756464611000351
(21) Anti-stress Effect of Green Tea with Lowered Caffeine on Humans: A Pilot Study https://www.jstage.jst.go.jp/article/bpb/40/6/40_b17-00141/_article
(22) Effect of green tea or green tea extract consumption on body weight and body composition; systematic review and meta-analysis https://pubmed.ncbi.nlm.nih.gov/24558988/
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