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Learning requires four things, a student, a teacher, understanding, and attendance. Remove any of those things and no knowledge can be passed. This was the case both 14,000 years ago and today. It hasn't changed.
The Teacher's Story
By firelight the teacher sketched out a plan on the cave wall with a piece of charcoal. In the drawing, lines of grass bent towards the stick figure hunters. In front of the hunters and grass were lovingly-drawn beasts, unaware of the hunter's approach.
The students listened closely, learning the proper way stalk their prey by moving into the wind so as to not alert it to their presence. As the teach talked, they all sipped from clay mugs of a tea supplied by the tribe's medicine man. Somehow it helped focus their minds but also, unbeknownst to the young hunters, it strengthen and empowered their immune systems. A student had to hear the wise teacher to grasp the concepts being taught. Fully optimized innate and active immune systems made sure they were present to learn the ways of the hunters!
The Immune Pill’s Components
ELDERBERRY Writings on black elder (Sambucus nigra) can be found as far back as one of the earliest known “doctors”, Hippocrates, who considered this tree to be “his medicine chest. This small tree thrived across Russia, Europe, and North America while other members of the elder family can be found in Asia, Australia, and South America. Strangely, Africa seems to lack any native elderberry. Wherever this genus grew early healers figured out the almost miraculous power its flowers and ripe berries in fighting viral and bacterial infections.*(1) The presence of elderberry meant the tribe had a powerful ally in the battle against disease, which traditionally have been the #1 cause of death throughout history. Modern sciences supports the ancient preventative and healing properties.*(2)
The berries are teaming with thousands of different compounds which assist the scouts, leaders, and fighters of the immune system.* Chemists have categorized these chemicals based on their primary structural features. Testing of these different molecules revealed assorted mechanisms by which they aid the body beyond just supporting the immune system.
Flavonoids: Research has shown quercetin can act as an anti-carcinogenic and anti-inflammatory agent, as well as attenuating lipid peroxidation, platelet aggregation and capillary permeability.*(3) Kaempferol has been reported to modulate signal transduction pathways responsible for apoptosis, angiogenesis, inflammation, and metastasis of cancer cells.*(4) Rutin’s secondary powers support the brain as protector against neuro-inflammation, guardian against convulsions, antidepressant mood lifter, return of motor control after a stroke, and reduce the uncontrolled movements caused by Alzheimer’s.*(5)
Phenolic Acids: Caffeic, chlorogenic, p-coumaric, ferulic, gallic, and syringic acids are powerful antioxidants which help rid the body of free radicals.*(6) Free radicals are highly reactive types of chemicals that damage the body at a cellular level, even down to your DNA. Such attacks on the DNA can lead to cellular mutations resulting in some forms of cancer.
In addition to these protective powers, phenolic acids also have secondary abilities. Chlorogenic acids have been found to reduce blood sugar levels.*(7). P-Coumaric acid helps fight inflammation.*(8) Ferulic acid may help with a variety of issues including Alzheimer’s, hardening of the arteries, cancer, high blood pressure, diabetes, menopause symptoms, and osteoporosis.*(9) Gallic acid is a potent antimicrobial compound and recent research shows it may help against Parkinson’s disease.*(10) Syringic acid benefits include use in prevention of diabetes, CVDs, cancer, cerebral ischemia; as well as it possessing antimicrobial, anti-inflammatory, antiendotoxic, neuro and hepatoprotective activities.*(11)
Sterols: B-sitosterol, campesterol, and stigmasterol are the primary sterols in elderberry. The amazing effects of B-sitosterol may include reducing enlarged prostate glands, blocking the body’s absorption of bad cholesterols, and of course, fighting infections.*(12) An interesting detail of its disease fighting is that it does this job even better in athletes compared to more stationary people.*(13) Meanwhile, campesterol is working behind the scenes to both try and kill cancer cells as well as reduce inflammations.* (14) Stigmasterol helps reduce LDL-induced proinflammatory cytokine secretion and so may help reduce the chance of the immune system overrespond with a dangerous cytokine cascade.*(15)
Anthocyanins: Brightly colored cyanidin 3- glucoside and cyanidin 3-sambubioside are a sub-class of flavonoids and are generally considered to be very powerful antioxidants.*(16) As usual, nature likes to multitask resulting in additional anthocyanin powers including maintaining the integrity of DNA, estrogenic action that reduces some hormone-dependent issues, reducing inflammations, and strengthening capillary walls. Anthocyanins also increase cytokine production, telling the body produce to produce more warrior cells to destroy infectious microbes.*(17) In elderberries, cyanidin 3- glucoside and cyanidin 3-sambubioside are the most common anthocyanins.
ECHINACEA There’s wonderful diversity of plants across the American Great Plains, many of which were used medicinally by the Native Americans of that land. Of these different plants the echinacea was held in highest regard by many tribes. The Pawnees, Omahas, Poncas, Lakota, Dakotas, Kiowas, Cheyannes, Mesquakies, Assiniboins, Hidatsa, Choctaws, Comanches, Meskawakis, Fox, Apaches, Kickapoos, and Potawatomis relied on it to maintain the health of their people by supporting their immune systems.*
Innate immunity is enhanced by echinacea by a combination of mechanisms such as activation of the neutrophils, macrophages, polymorphonuclear leukocytes (PMN), and natural killer (NK) cells making it a strong antiviral and antibacterial herb.*(18) Additionally, research shows it has anti-inflammatory, antianxiety, and anticancer compounds.*(18)
Alkamides: This class of chemicals function as part of the human body’s cannabinoid receptor system, which plays a role in activation of the immune system, prepping it for action by increasing the available amounts of cyclic adenosine monophosphate, p38 mitogen-activated protein kinases, and c-Jun N-terminal kinases.(18) In addition, this stimulation of the cannabinoid system by echinacea has been shown to reduce anxiety.*(18) Research also suggests these molecules activate the immune system’s B-cells whose job is to produce the antibodies used to tag invaders.*(18) Echinacea’s alkamides may be immunomodulators which maintain the proper scale of response by the immune system, increasing it if needed, decreasing it if the response became big enough to damage the body’s own cells.*(18) At the same time it is a super-stimulator of interleukin-10, one of the body’s primary anti-inflammation agents.*(18) Along with the interleukin-10 it also stimulates production of nitric oxide which helps with both inflammation as well as relaxing blood vessel walls allowing the heart to pump more blood at lower pressures.*(18)
Polysaccharides: This class of echinacea compounds reportedly increases production of interleukin-1, interleukin-6, and TNF-α which respond strongly against bacteria including Candida albicans and Listeria monocytogenes.*(18) Cytotoxicity against certain colon cancer and leukemic cells in another benefit of echinacea polysaccharides.*(18)
CORDYCEPS MUSHROOM Ancient Tibetan and Sikkim medical texts talk about the powers of this strange mushroom. Traditionally it was used to support the blood, liver, endocrine system, heart & circulation, immune system, sexual & endurance activities, and to fight cancers, all of which have been confirmed by Western science.*(19)
Cordyceps mushrooms have a bidirectional modulatory effect on the immune system, similar to echinacea’s alkamides. When needed, the fungi will speed the formation and action of the immune system’s scout, director, and warrior cells. However, in the case autoimmune disorders, inflammations, or other situations where the body has begun attacking itself cordyceps can “dial down” the response, reducing this self-damage.*(19) This dialing down of the immune system has led to its use reducing the effects of autoimmune diseases such as Lupus as well as suppressing the immune system of organ transplant patients.*(19) It increases cytokine production as needed to respond to infections without triggering a cytokine cascade.*(19) The dialing up of the immune system is particularly active in the gastrointestinal tract from the mouth (including tonsils and adenoids) to all the way down through intestines.*(19)
In addition to raising/lowering immune system responses cordyceps are also potent anti-inflammatory agents.* The general mechanism is to increase the body’s production of nitric oxide which interferes with inflammation response.*(19) This increased nitric oxide also improves overall endurance by improving blood flow which increase delivery of oxygen to and removal of work-produced waste products from muscles during strenuous activities.*(19)
Blood sugar control is another power of cordyceps. This mushroom increases rate of whole-body glucose disposal in healthy recipients and lowering fasting glucose levels in those with diabetes mellitus.*(19) Equally important, cordyceps offer liver and kidney-protecting properties, protecting these organ from chronic chemical damage and increasing overall function.*(19)
All these properties come from a huge assortment of chemical compounds produced by this fungi. Nucleosides such as adenosine, cytidine, cytosine, guanine, guanosine, uracil, uridine, hypoxanthine, inosine, thymine, thymidine, and more; sterols including ergosterol, H1-A, Δ3ergosterol, ergosterol peroxide, ergosteryl-3-0-β- D-glucopyranoside, cereisterol, β-sitosterol, daucosterol, cholesterol, 22, 23-dihydroergosteryl-3- O-β-D-glucopyranoside, cholesteryl palmitate, campesterol, and dihydrobrassicasterol; the fatty acids lauric acid, myristic acid, pentadecanoic acid, palmitoleic acid, palmitic acid, linoleic acid, oleic acid, stearic acid, docosanoic acid, and lignoceric acid; and of course a high concentration of beneficial polysaccharides.
SELF HEAL This common mint is found all around the world. Every culture that encountered it, from Japanese samurai to Celtic druids to Native American warriors, have harnessed self heal’s properties. Its traditional uses include treating viral infections, pinkeye and other internal & external bacterial infections, anti-cancer, fevers, weak hearts, malfunctioning livers, thyroid issues, poorly healing wounds, diabetes, kidney issues, headaches, skin irritations, swollen lymph nodes, and assorted inflammations.* Modern science has confirmed the triterenoids, saponins, phenolic acids, sterols, glycosides, flavonoids, and organic acids function as antiviral, antibacterial, anti-inflammatory, immunoregulatory, anti-oxidative, anti-tumor, antihypertensive and hypoglycemic functions.*(22)
Like most mints, self heal is loaded with assorted chemical compounds including rosmaric acid, rutin, delphinidin, oleanolic acid, betulinic acid, camphor, tannins, and even manganese. Somewhat unusual, it’s also a rich source of polysaccharides. These polysaccharides are one of the key sources of self heal’s immune system stimulation, having been shown to trigger a more vigorous response of T and B type white blood cells, who’s purpose is to seek out and destroy invaders.*(21)
The key to Self Heal’s properties comes from this combination of its different compounds. Research has shown that its mixture of triterpenes, phenolics, and polysaccharides work together to fight lung, breast, gastric, and liver cancers.*(23) The mechanism seems to be enhanced production of TNF-α cytokine cells. These specialized cells of the immune system are known to enhance the effectiveness of anticancer drugs, target and slow the growth of tumor vascular epithelial cells, weaken the blood vessels inside tumors, and selectively increase the rate of cancer cell death.*(24)
VITAMIN C Everyone knows vitamin C is important, but few know why it’s important. The human body can’t make or store this critical nutrient, so it needs a daily dose of approximately 150mg. Once in the body its special ability to donate electrons makes it a necessary cofactor all sorts of different biochemical enzymatic reactions. Its work in the immune system begins at the skin, maintaining it as a strong barrier against infectious invaders.*(20) It serves a similar purpose inside the lungs, helping them resist entrance into the body of microbes and viruses.*(20) One class of immune system “warrior” cells uses vitamin C to biodegrade the foreign materials these phagocytic cells consume.(20) Vitamin C is also the signal molecule used by director cells to signal the production levels of B-type and T-type immunity cells.(20)
The combination of elderberry, echinacea, cordyceps, self heal, and vitamin C work together in The Immune Pill to support multiple aspects of the immune system.* The doses of the individual components were set to give your body enough of the plants & mushroom to get the proper effect without excess or under-representation. Ancient wisdom and modern science come together, unearthing the ancestral secrets used to maintain the tribe’s health. You are part of this tribe!
(3) Quercetin: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808895/
(4) Kaempferol: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601579/
(6) Elderberry Phenolic Acids: https://www.ncbi.nlm.nih.gov/pubmed/28084608
(7) Chlorogenic Acids: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766985/
(8) P-Coumaric Acid: https://www.hindawi.com/journals/ecam/2018/5198594/
(9) Ferulic Acid: https://www.verywellhealth.com/the-benefits-of-ferulic-acid-89607
(10) Gallic Acid: https://www.ncbi.nlm.nih.gov/pmc/?term=gallic+acid
(11) Syringic Acid: https://www.sciencedirect.com/science/article/pii/S0753332218347589?via%3Dihub
(12) B-sitosterol: https://wa.kaiserpermanente.org/kbase/topic.jhtml?docId=hn-2806008
(11) Campesterol: https://www.mdpi.com/1420-3049/22/1/118/htm
(12-13) B-sitosterol: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5297648/
(15) Stigmasterol: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573401/
(16-17) Anthocyanins: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1082894/
(18) Echinacea: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441164/
(20) Self Heal: https://pubmed.ncbi.nlm.nih.gov/26988527/
The Immune Pill Components
LION’S MANE MUSHROOM Hericium erinaceus aka lion’s mane is found growing wild across many parts of the world. Rather than looking like a traditional toadstool, these fungi resemble a cluster of small, white tubes giving the appearance of a round, albino hedgehog growing off the side of a tree. The earliest records of the mental support offered by these odd fungi can be traced to ancient China. Although the whole mushroom is edible and unbelievably delicious, when used to maintain mental acuity they were brewed into a simple tea.
β-glucan polysaccharides: This water-soluble class of compounds are the key source of lion’s mane’s power. Studies have shown these polysaccharides are the anti-cancer, immuno-modulating, hypolipidemic, antioxidant, anti-microbial, anti-hypertensive, anti-diabetic, wound healing, and neuro-protective agents of Hericium erianceus.*(1) The potent brain support comes from maintaining and even increasing neural connectivity while also helping clear the brain of damaging compounds, leading to improved spatial and visual memory.*(2) These benefits were found in elderly patients as well as people with Alzheimer’s and Parkinson’s.*(2) Motor control improved in extremities that had suffered nerve damage.*(2) For consistency The Immune Pill uses a scientifically controlled hot water extraction of lion’s mane mushrooms followed by careful removal of the water. This ensures the concentration of β-glucan polysaccharides in the capsule meets our special requirements to best serve your needs.
GINKGO There’s something special about this ancient tree. Fossil records put it back to 270 million years ago, well before the evolution of humans as well as many other things currently living on the planet. An individual tree can live over 1500 years, as proven by examples grown in Chinese, Korean, and Japanese gardens. Use in traditional Asian medicine goes back even farther. It’s this use that has helped preserve ginkgo trees when humans have sent so many other species into the abyss. While ginkgo has been used by Asian healers for circulatory disorders, asthma, tinnitus, and vertigo, its main use is for mental/cognitive support such as autism, ADHD, addiction, anxiety, schizophrenia, and dementia.*(3)
Research suggests the neuro-benefits of ginkgo are due to several mechanisms triggered by multiple compounds. Increased blood flow to the brain is one.*(4) Presence of the monoamine oxidase inhibitor kaempferol may also play a role.*(5) Compounds from ginkgo have also been shown to modulate the over-expression of cerebral proteins associated with Alzheimer’s.*(6) Whatever the actual chemistry may be, the end result has been known and used for a long, long time.
SAGE The history of Salvia officinalis reaches back to pre-Roman times along the Mediterranean Sea. By the times the Roman culture appeared it already was known as the “holy herb” used as a local anesthetic of the skin, a diuretic, and to stop bleeding. The ancient philosopher/doctors Dioscorides, Pliny, and Galen all wrote of its powers. Because of the rich flavor of sage’s compounds such as cineole, borneol, thujone, tannic acid, oleic acid, ursonic acid, ursolic acid, carnosol, carnosic acid, fumaric acid, chlorogenic acid, caffeic acid, niacin, nicotinamide, flavones, and flavonoid glycosides its usage moved from healer to the cook…and to those who required a sharp mind.
Research has shown sage assists with attention, memory, judgment and evaluation, reasoning, problem solving and decision making through a large diversity of mechanisms.*(7) Compounds exert cholinergic, neurotrophic, anti-inflammatory, antidepressant, anxiolytic, antioxidant effects on the brain as well as reducing the damage done by amyloid-β peptide clusters of Alzheimer’s.*(4)
The mixture of phenolic acid and flavoids , rosmarinic acid, salvianolic acid, carnosic acid, and quercetin work together to return memory functions in those showing signs of Alzheimer’s by slowing the growth of amyloid-β peptide clusters which results in a reduction of the damaging compounds these clusters produce.*(7)
Acetylcholine is a primary neurotransmitter of the cholinergic signaling system in the brain. This system plays a large role in mood, memory, and general motivation. The enzyme AChE breaks down acetylcholine. When AChE becomes overexpressed the availability of acetylcholine drops below what is necessary for normal cognitive functions. Rosmarinic acid, carnosic acid, and quercetin inhibit the action of AChE, maintaining normal levels of acetylcholine.*(7)
Neurotrophins are the general name for the compounds that regulate neuron development, functioning, adaptability, and survival. In other words, they build and maintain the amazing computer circuitry of your brain. Brain-derived neurotrophic factor (BDNF) is a compound in the brain found to assist the proper growth and functioning of neurons. Reduced levels of BDNF result in impaired metal ability. The rosmarinic acid in sage increases BDNF levels back to operational levels.*(7)
Brain inflammations have been found to correspond with assorted neurological impairments including ADHD, reduced motor control, depression, and acute phase psychosis. The 1,8-cineole, camphor, carnosol, and carnosic acids found in sage reduces these inflammations, usually through reduction of cytokine expression.*(7)
Rosmarinic and caffeic acids, also both display antidepressant and antianxiety activity. All that is known about the actual mechanisms of these plant compounds is that they don’t function like the monoamine oxidase inhibitors created in the lab.*(7)
Together, the combination of lion’s man mushroom, ginger, and sage in The Brain Pill work across a diversity of mechanisms to maintain your cognitive abilities. The doses of the individual components were set to give your body enough of the plants & mushroom necessary for the proper effect without over or under-representation. Ancient wisdom and modern science come together, unearthing the ancestral secrets used to maintain the tribe’s health. You are part of this tribe!
*FDA Disclaimer: The statements made regarding these products have not been evaluated by the Food and Drug Administration. The efficacy of these products has not been confirmed by FDA-approved research. These products are not intended to diagnose, treat, cure or prevent any disease.
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